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Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer
Insulin-like growth factor-I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation, and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF receptor (IGF-IR), however IGF-I signaling v...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602724/ https://www.ncbi.nlm.nih.gov/pubmed/23519101 http://dx.doi.org/10.3389/fendo.2013.00031 |
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author | Philippou, Anastassios Armakolas, Athanasios Koutsilieris, Michael |
author_facet | Philippou, Anastassios Armakolas, Athanasios Koutsilieris, Michael |
author_sort | Philippou, Anastassios |
collection | PubMed |
description | Insulin-like growth factor-I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation, and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF receptor (IGF-IR), however IGF-I signaling via insulin receptor (IR) and hybrid IGF-I/IR is also evident. Different IGF-I mRNA splice variants, namely IGF-IEa, IGF-IEb, and IGF-IEc, are expressed in human cells and tissues. These transcripts encode several IGF-I precursor proteins which contain the same bioactive product (mature IGF-I), however, they differ by the length of their signal peptides on the amino-terminal end and the structure of the extension peptides (E-peptides) on the carboxy-terminal end. There is an increasing interest in the possible different role of the IGF-I transcripts and their respective non-(mature)IGF-I products in the regulation of distinct biological activities. Moreover, there is strong evidence of a differential expression profile of the IGF-I splice variants in normal versus PCa tissues and PCa cells, implying that the expression pattern of the various IGF-I transcripts and their respective protein products may possess different functions in cancer biology. Herein, the evidence that the IGF-IEc transcript regulates PCa growth via Ec peptide specific and IGF-IR/IR-independent signaling is discussed. |
format | Online Article Text |
id | pubmed-3602724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36027242013-03-21 Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer Philippou, Anastassios Armakolas, Athanasios Koutsilieris, Michael Front Endocrinol (Lausanne) Endocrinology Insulin-like growth factor-I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation, and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF receptor (IGF-IR), however IGF-I signaling via insulin receptor (IR) and hybrid IGF-I/IR is also evident. Different IGF-I mRNA splice variants, namely IGF-IEa, IGF-IEb, and IGF-IEc, are expressed in human cells and tissues. These transcripts encode several IGF-I precursor proteins which contain the same bioactive product (mature IGF-I), however, they differ by the length of their signal peptides on the amino-terminal end and the structure of the extension peptides (E-peptides) on the carboxy-terminal end. There is an increasing interest in the possible different role of the IGF-I transcripts and their respective non-(mature)IGF-I products in the regulation of distinct biological activities. Moreover, there is strong evidence of a differential expression profile of the IGF-I splice variants in normal versus PCa tissues and PCa cells, implying that the expression pattern of the various IGF-I transcripts and their respective protein products may possess different functions in cancer biology. Herein, the evidence that the IGF-IEc transcript regulates PCa growth via Ec peptide specific and IGF-IR/IR-independent signaling is discussed. Frontiers Media S.A. 2013-03-20 /pmc/articles/PMC3602724/ /pubmed/23519101 http://dx.doi.org/10.3389/fendo.2013.00031 Text en Copyright © 2013 Philippou, Armakolas and Koutsilieris. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Endocrinology Philippou, Anastassios Armakolas, Athanasios Koutsilieris, Michael Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer |
title | Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer |
title_full | Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer |
title_fullStr | Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer |
title_full_unstemmed | Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer |
title_short | Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer |
title_sort | evidence for the possible biological significance of the igf-1 gene alternative splicing in prostate cancer |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602724/ https://www.ncbi.nlm.nih.gov/pubmed/23519101 http://dx.doi.org/10.3389/fendo.2013.00031 |
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