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Evidence for the Possible Biological Significance of the igf-1 Gene Alternative Splicing in Prostate Cancer

Insulin-like growth factor-I (IGF-I) has been implicated in the pathogenesis of prostate cancer (PCa), since it plays a key role in cell proliferation, differentiation, and apoptosis. The IGF-I actions are mediated mainly via its binding to the type I IGF receptor (IGF-IR), however IGF-I signaling v...

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Detalles Bibliográficos
Autores principales:	Philippou, Anastassios, Armakolas, Athanasios, Koutsilieris, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602724/ https://www.ncbi.nlm.nih.gov/pubmed/23519101 http://dx.doi.org/10.3389/fendo.2013.00031

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