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Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics
Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the oncoproteins that drive cancer progression. Its actions depend upon its essential ATPase, an activity fortuitously inhibited with a very high degree of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603443/ https://www.ncbi.nlm.nih.gov/pubmed/23271830 http://dx.doi.org/10.1098/rsob.120138 |