Mammalian Target of Rapamycin Inhibitors Induce Tumor Cell Apoptosis In Vivo Primarily by Inhibiting VEGF Expression and Angiogenesis

We found that rapalog mTOR inhibitors induce G1 arrest in the PTEN-null HS Sultan B-cell lymphoma line in vitro, but that administration of rapalogs in a HS Sultan xenograft model resulted in significant apoptosis, and that this correlated with induction of hypoxia and inhibition of neoangiogenesis...

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Detalles Bibliográficos
Autores principales: Frost, Patrick, Berlanger, Eileen, Mysore, Veena, Hoang, Bao, Shi, YiJiang, Gera, Joseph, Lichtenstein, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603547/
https://www.ncbi.nlm.nih.gov/pubmed/23533410
http://dx.doi.org/10.1155/2013/897025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603547/
https://www.ncbi.nlm.nih.gov/pubmed/23533410
http://dx.doi.org/10.1155/2013/897025

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