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Functions of BCL-X(L) at the Interface between Cell Death and Metabolism

The BCL-2 homolog BCL-X(L), one of the two protein products of BCL2L1, has originally been characterized for its prominent prosurvival functions. Similar to BCL-2, BCL-X(L) binds to its multidomain proapoptotic counterparts BAX and BAK, hence preventing the formation of lethal pores in the mitochond...

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Detalles Bibliográficos
Autores principales: Michels, Judith, Kepp, Oliver, Senovilla, Laura, Lissa, Delphine, Castedo, Maria, Kroemer, Guido, Galluzzi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603586/
https://www.ncbi.nlm.nih.gov/pubmed/23533418
http://dx.doi.org/10.1155/2013/705294