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Gene Therapy with HSV1-sr39TK/GCV Exhibits a Stronger Therapeutic Efficacy Than HSV1-TK/GCV in Rat C6 Glioma Cells

Although the combination of herpes simplex virus type 1 (HSV-1) thymidine kinase (TK) with ganciclovir (GCV) has been shown as a promising suicide gene treatment strategy for glioma, the almost immunodepressive dose of GCV required for its adequate in vivo efficacy has hampered its further clinical...

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Detalles Bibliográficos
Autores principales:	Li, Lei-qing, Shen, Fang, Xu, Xiao-yan, Zhang, Hong, Yang, Xiao-feng, Liu, Wei-guo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603674/ https://www.ncbi.nlm.nih.gov/pubmed/23533367 http://dx.doi.org/10.1155/2013/951343

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