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Pioglitazone Improves Cognitive Function via Increasing Insulin Sensitivity and Strengthening Antioxidant Defense System in Fructose-Drinking Insulin Resistance Rats

Insulin resistance (IR) links Alzheimer’s disease (AD) with oxidative damage, cholinergic deficit, and cognitive impairment. Peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone previously used to treat type 2 diabetes mellitus (T2DM) has also been demonstrated to be effective i...

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Detalles Bibliográficos
Autores principales:	Yin, Qing-Qing, Pei, Jin-Jing, Xu, Song, Luo, Ding-Zhen, Dong, Si-Qing, Sun, Meng-Han, You, Li, Sun, Zhi-Jian, Liu, Xue-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603906/ https://www.ncbi.nlm.nih.gov/pubmed/23527159 http://dx.doi.org/10.1371/journal.pone.0059313

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