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Inhibition of Histone Deacetylase Impacts Cancer Stem Cells and Induces Epithelial-Mesenchyme Transition of Head and Neck Cancer

The genome is organized and packed into the nucleus through interactions with core histone proteins. Emerging evidence suggests that tumors are highly responsive to epigenetic alterations that induce chromatin-based events and dynamically influence tumor behavior. We examined chromatin organization...

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Detalles Bibliográficos
Autores principales: Giudice, Fernanda S., Pinto, Decio S., Nör, Jacques E., Squarize, Cristiane H., Castilho, Rogerio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603970/
https://www.ncbi.nlm.nih.gov/pubmed/23527004
http://dx.doi.org/10.1371/journal.pone.0058672