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Pharmacological Inhibition of Glycogen Synthase Kinase 3 Regulates T Cell Development In Vitro

The development of functional T cells requires receptor-mediated transition through multiple checkpoints in the thymus. Double negative 3 (DN3) thymocytes are selected for the presence of a rearranged TCR beta chain in a process termed β-selection which requires signalling via the pre-TCR, Notch1 an...

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Detalles Bibliográficos
Autores principales:	Schroeder, Jan-Hendrik, Bell, Lewis S., Janas, Michelle L., Turner, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603984/ https://www.ncbi.nlm.nih.gov/pubmed/23526989 http://dx.doi.org/10.1371/journal.pone.0058501

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