Rectal Transmission of Transmitted/Founder HIV-1 Is Efficiently Prevented by Topical 1% Tenofovir in BLT Humanized Mice

Rectal microbicides are being developed to prevent new HIV infections in both men and women. We focused our in vivo preclinical efficacy study on rectally-applied tenofovir. BLT humanized mice (n = 43) were rectally inoculated with either the primary isolate HIV-1(JRCSF) or the MSM-derived transmitt...

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Detalles Bibliográficos
Autores principales: Chateau, Morgan L., Denton, Paul W., Swanson, Michael D., McGowan, Ian, Garcia, J. Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603991/
https://www.ncbi.nlm.nih.gov/pubmed/23527295
http://dx.doi.org/10.1371/journal.pone.0060024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603991/
https://www.ncbi.nlm.nih.gov/pubmed/23527295
http://dx.doi.org/10.1371/journal.pone.0060024

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