Free Fatty Acid Induces Endoplasmic Reticulum Stress and Apoptosis of β-cells by Ca(2+)/Calpain-2 Pathways

Dysfunction of β-cells is a major characteristic in the pathogenesis of type 2 diabetes mellitus (T2DM). The combination of obesity and T2DM is associated with elevated plasma free fatty acids (FFAs). However, molecular mechanisms linking FFAs to β-cell dysfunction remain poorly understood. In the p...

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Detalles Bibliográficos
Autores principales: Cui, Wei, Ma, Jie, Wang, Xingqin, Yang, Wenjuan, Zhang, Jing, Ji, Qiuhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604010/
https://www.ncbi.nlm.nih.gov/pubmed/23527285
http://dx.doi.org/10.1371/journal.pone.0059921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604010/
https://www.ncbi.nlm.nih.gov/pubmed/23527285
http://dx.doi.org/10.1371/journal.pone.0059921

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