Chemerin Is an Antimicrobial Agent in Human Epidermis

Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of b...

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Detalles Bibliográficos
Autores principales: Banas, Magdalena, Zabieglo, Katarzyna, Kasetty, Gopinath, Kapinska-Mrowiecka, Monika, Borowczyk, Julia, Drukala, Justyna, Murzyn, Krzysztof, Zabel, Brian A., Butcher, Eugene C., Schroeder, Jens M., Schmidtchen, Artur, Cichy, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604073/
https://www.ncbi.nlm.nih.gov/pubmed/23527010
http://dx.doi.org/10.1371/journal.pone.0058709
Descripción
Sumario:Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val(66)-Pro(85), which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.

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