Allosteric Inhibition of Hypoxia Inducible Factor-2 with Small Molecules

Hypoxia Inducible Factors (HIFs) are heterodimeric transcription factors induced in many cancers where they frequently promote the expression of many protumorigenic pathways. Though transcription factors are typically considered “undruggable”, the PAS-B domain of the HIF-2α subunit contains a large...

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Detalles Bibliográficos
Autores principales: Scheuermann, Thomas H, Li, Qiming, Ma, He-Wen, Key, Jason, Zhang, Lei, Chen, Rui, Garcia, Joseph A, Naidoo, Jacinth, Longgood, Jamie, Frantz, Doug E, Tambar, Uttam K, Gardner, Kevin H, Bruick, Richard K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604136/
https://www.ncbi.nlm.nih.gov/pubmed/23434853
http://dx.doi.org/10.1038/nchembio.1185

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604136/
https://www.ncbi.nlm.nih.gov/pubmed/23434853
http://dx.doi.org/10.1038/nchembio.1185

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