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Comparison of the transport of QX-314 through TRPA1, TRPM8, and TRPV1 channels
BACKGROUND: It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin is problematic in therapeutic use because it induces firing...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604974/ https://www.ncbi.nlm.nih.gov/pubmed/23525210 http://dx.doi.org/10.2147/JPR.S41614 |