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Protein–peptide complex crystallization: a case study on the ERK2 mitogen-activated protein kinase
Linear motifs normally bind with only medium binding affinity (K (d) of ∼0.1–10 µM) to shallow protein-interaction surfaces on their binding partners. The crystallization of proteins in complex with linear motif-containing peptides is often challenging because the energy gained upon crystal packing...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605046/ https://www.ncbi.nlm.nih.gov/pubmed/23519423 http://dx.doi.org/10.1107/S0907444912051062 |