Fine Characterisation of a Recombination Hotspot at the DPY19L2 Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population

We demonstrated previously that 75% of infertile men with round, acrosomeless spermatozoa (globozoospermia) had a homozygous 200-Kb deletion removing the totality of DPY19L2. We showed that this deletion occurred by Non-Allelic Homologous Recombination (NAHR) between two homologous 28-Kb Low Copy Re...

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Detalles Bibliográficos
Autores principales: Coutton, Charles, Abada, Farid, Karaouzene, Thomas, Sanlaville, Damien, Satre, Véronique, Lunardi, Joël, Jouk, Pierre-Simon, Arnoult, Christophe, Thierry-Mieg, Nicolas, Ray, Pierre F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605140/
https://www.ncbi.nlm.nih.gov/pubmed/23555282
http://dx.doi.org/10.1371/journal.pgen.1003363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605140/
https://www.ncbi.nlm.nih.gov/pubmed/23555282
http://dx.doi.org/10.1371/journal.pgen.1003363

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