Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts β-cell survival and proliferation differentially in vitro and in vivo

Type 1 Diabetes is characterized by an absolute insulin deficiency due to the autoimmune destruction of insulin producing β-cells in the pancreatic islets. Akt1/Protein Kinase B is the direct downstream target of PI3 Kinase activation, and has shown potent anti-apoptotic and proliferation-inducing a...

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Detalles Bibliográficos
Autores principales: Bone, Robert N., Icyuz, Mert, Zhang, Yanqing, Zhang, Yuan, Cui, Wanxing, Wang, Hongjun, Peng, Ji-Bin, Matthews, Qiana L., Siegal, Gene P., Wu, Hongju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605165/
https://www.ncbi.nlm.nih.gov/pubmed/23183538
http://dx.doi.org/10.4161/isl.22721

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605165/
https://www.ncbi.nlm.nih.gov/pubmed/23183538
http://dx.doi.org/10.4161/isl.22721

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