A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype

The CDKN1B gene encodes the cyclin-dependent kinase inhibitor p27(KIP1), an atypical tumor suppressor playing a key role in cell cycle regulation, cell proliferation, and differentiation. Impaired p27(KIP1) expression and/or localization are often observed in tumor cells, further confirming its cent...

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Detalles Bibliográficos
Autores principales: Occhi, Gianluca, Regazzo, Daniela, Trivellin, Giampaolo, Boaretto, Francesca, Ciato, Denis, Bobisse, Sara, Ferasin, Sergio, Cetani, Filomena, Pardi, Elena, Korbonits, Márta, Pellegata, Natalia S., Sidarovich, Viktoryia, Quattrone, Alessandro, Opocher, Giuseppe, Mantero, Franco, Scaroni, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605397/
https://www.ncbi.nlm.nih.gov/pubmed/23555276
http://dx.doi.org/10.1371/journal.pgen.1003350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605397/
https://www.ncbi.nlm.nih.gov/pubmed/23555276
http://dx.doi.org/10.1371/journal.pgen.1003350

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