Elevated Granzyme B in Cytotoxic Lymphocytes is a Signature of Immune Activation in Hemophagocytic Lymphohistiocytosis

Patients with hemophagocytic lymphohistiocytosis (HLH) exhibit immune hyper-activation as a consequence of genetic defects in secretory granule proteins of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Murine models of HLH demonstrate significant activation of CTL as central to the di...

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Detalles Bibliográficos
Autores principales: Mellor-Heineke, Sabine, Villanueva, Joyce, Jordan, Michael B., Marsh, Rebecca, Zhang, Kejian, Bleesing, Jack J., Filipovich, Alexandra H., Risma, Kimberly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605512/
https://www.ncbi.nlm.nih.gov/pubmed/23524976
http://dx.doi.org/10.3389/fimmu.2013.00072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605512/
https://www.ncbi.nlm.nih.gov/pubmed/23524976
http://dx.doi.org/10.3389/fimmu.2013.00072

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