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Chromosome Segregation: Disarming the Protector

One of the key features of meiosis is that shugoshin in complex with protein phosphatase 2A (PP2A) protects centromeric cohesin during meiosis I, but not during meiosis II. A new model suggests that a PP2A inhibitor mediates deprotection of centromeric cohesin during meiosis II.

Detalles Bibliográficos
Autores principales: Sanyal, Swastika, Kovacikova, Ines, Gregan, Juraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605575/
https://www.ncbi.nlm.nih.gov/pubmed/23518053
http://dx.doi.org/10.1016/j.cub.2013.02.028