Chromosome Segregation: Disarming the Protector

One of the key features of meiosis is that shugoshin in complex with protein phosphatase 2A (PP2A) protects centromeric cohesin during meiosis I, but not during meiosis II. A new model suggests that a PP2A inhibitor mediates deprotection of centromeric cohesin during meiosis II.

Detalles Bibliográficos
Autores principales: Sanyal, Swastika, Kovacikova, Ines, Gregan, Juraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605575/
https://www.ncbi.nlm.nih.gov/pubmed/23518053
http://dx.doi.org/10.1016/j.cub.2013.02.028
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author Sanyal, Swastika
Kovacikova, Ines
Gregan, Juraj
author_facet Sanyal, Swastika
Kovacikova, Ines
Gregan, Juraj
author_sort Sanyal, Swastika
collection PubMed
description One of the key features of meiosis is that shugoshin in complex with protein phosphatase 2A (PP2A) protects centromeric cohesin during meiosis I, but not during meiosis II. A new model suggests that a PP2A inhibitor mediates deprotection of centromeric cohesin during meiosis II.
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spelling pubmed-36055752013-03-22 Chromosome Segregation: Disarming the Protector Sanyal, Swastika Kovacikova, Ines Gregan, Juraj Curr Biol Dispatch One of the key features of meiosis is that shugoshin in complex with protein phosphatase 2A (PP2A) protects centromeric cohesin during meiosis I, but not during meiosis II. A new model suggests that a PP2A inhibitor mediates deprotection of centromeric cohesin during meiosis II. Cell Press 2013-03-18 /pmc/articles/PMC3605575/ /pubmed/23518053 http://dx.doi.org/10.1016/j.cub.2013.02.028 Text en © 2013 ELL & Excerpta Medica. This document may be redistributed and reused, subject to certain conditions (http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0) .
spellingShingle Dispatch
Sanyal, Swastika
Kovacikova, Ines
Gregan, Juraj
Chromosome Segregation: Disarming the Protector
title Chromosome Segregation: Disarming the Protector
title_full Chromosome Segregation: Disarming the Protector
title_fullStr Chromosome Segregation: Disarming the Protector
title_full_unstemmed Chromosome Segregation: Disarming the Protector
title_short Chromosome Segregation: Disarming the Protector
title_sort chromosome segregation: disarming the protector
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605575/
https://www.ncbi.nlm.nih.gov/pubmed/23518053
http://dx.doi.org/10.1016/j.cub.2013.02.028
work_keys_str_mv AT sanyalswastika chromosomesegregationdisarmingtheprotector
AT kovacikovaines chromosomesegregationdisarmingtheprotector
AT greganjuraj chromosomesegregationdisarmingtheprotector

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