Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics'

A major obstacle to the efficient production of antibody conjugates for therapy and diagnosis is the non-ideal performance of commonly used chemical methods for the attachment of effector-molecules to the antibody of interest. Here we demonstrate that this limitation can be simply addressed using 3,...

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Detalles Bibliográficos
Autores principales: Schumacher, Felix F., Sanchania, Vishal A., Tolner, Berend, Wright, Zoë V. F., Ryan, Chris P., Smith, Mark E. B., Ward, John M., Caddick, Stephen, Kay, Christopher W. M., Aeppli, Gabriel, Chester, Kerry A., Baker, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605607/
https://www.ncbi.nlm.nih.gov/pubmed/23519366
http://dx.doi.org/10.1038/srep01525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605607/
https://www.ncbi.nlm.nih.gov/pubmed/23519366
http://dx.doi.org/10.1038/srep01525

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