Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module

Mitogen-activated protein kinase (MAPK) activation depends on a linear binding motif found in all MAPK kinases (MKK). In addition, the PB1 (Phox and Bem1) domain of MKK5 is required for extracellular signal regulated kinase 5 (ERK5) activation. We present the crystal structure of ERK5 in complex wit...

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Detalles Bibliográficos
Autores principales: Glatz, Gábor, Gógl, Gergő, Alexa, Anita, Reményi, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605678/
https://www.ncbi.nlm.nih.gov/pubmed/23382384
http://dx.doi.org/10.1074/jbc.M113.452235

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605678/
https://www.ncbi.nlm.nih.gov/pubmed/23382384
http://dx.doi.org/10.1074/jbc.M113.452235

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