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TRPM2 links oxidative stress to the NLRP3 inflammasome activation

Exposure to particulate crystals can induce oxidative stress in phagocytes, which triggers NLRP3 inflammasome-mediated interleukin 1β (IL-1β) secretion to initiate undesirable inflammatory responses that are associated with both autoinflammatory and metabolic diseases. Although mitochondrial reactiv...

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Detalles Bibliográficos
Autores principales:	Zhong, Zhenyu, Zhai, Yougang, Liang, Shuang, Mori, Yasuo, Han, Renzhi, Sutterwala, Fayyaz S, Qiao, Liang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605705/ https://www.ncbi.nlm.nih.gov/pubmed/23511475 http://dx.doi.org/10.1038/ncomms2608

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