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New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood(1). Previous genome-wide association studies identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes, and...

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Autores principales: Horikoshi, Momoko, Yaghootkar, Hanieh, Mook-Kanamori, Dennis O., Sovio, Ulla, Taal, H. Rob, Hennig, Branwen J., Bradfield, Jonathan P., St. Pourcain, Beate, Evans, David M., Charoen, Pimphen, Kaakinen, Marika, Cousminer, Diana L., Lehtimäki, Terho, Kreiner-Møller, Eskil, Warrington, Nicole M., Bustamante, Mariona, Feenstra, Bjarke, Berry, Diane J., Thiering, Elisabeth, Pfab, Thiemo, Barton, Sheila J., Shields, Beverley M., Kerkhof, Marjan, van Leeuwen, Elisabeth M., Fulford, Anthony J., Kutalik, Zoltán, Zhao, Jing Hua, den Hoed, Marcel, Mahajan, Anubha, Lindi, Virpi, Goh, Liang-Kee, Hottenga, Jouke-Jan, Wu, Ying, Raitakari, Olli T., Harder, Marie N., Meirhaeghe, Aline, Ntalla, Ioanna, Salem, Rany M., Jameson, Karen A., Zhou, Kaixin, Monies, Dorota M., Lagou, Vasiliki, Kirin, Mirna, Heikkinen, Jani, Adair, Linda S., Alkuraya, Fowzan S., Al-Odaib, Ali, Amouyel, Philippe, Andersson, Ehm Astrid, Bennett, Amanda J., Blakemore, Alexandra I.F., Buxton, Jessica L., Dallongeville, Jean, Das, Shikta, de Geus, Eco J. C., Estivill, Xavier, Flexeder, Claudia, Froguel, Philippe, Geller, Frank, Godfrey, Keith M., Gottrand, Frédéric, Groves, Christopher J., Hansen, Torben, Hirschhorn, Joel N., Hofman, Albert, Hollegaard, Mads V., Hougaard, David M., Hyppönen, Elina, Inskip, Hazel M., Isaacs, Aaron, Jørgensen, Torben, Kanaka-Gantenbein, Christina, Kemp, John P., Kiess, Wieland, Kilpeläinen, Tuomas O., Klopp, Norman, Knight, Bridget A., Kuzawa, Christopher W., McMahon, George, Newnham, John P., Niinikoski, Harri, Oostra, Ben A., Pedersen, Louise, Postma, Dirkje S., Ring, Susan M., Rivadeneira, Fernando, Robertson, Neil R., Sebert, Sylvain, Simell, Olli, Slowinski, Torsten, Tiesler, Carla M.T., Tönjes, Anke, Vaag, Allan, Viikari, Jorma S., Vink, Jacqueline M., Vissing, Nadja Hawwa, Wareham, Nicholas J., Willemsen, Gonneke, Witte, Daniel R., Zhang, Haitao, Zhao, Jianhua, Wilson, James F., Stumvoll, Michael, Prentice, Andrew M., Meyer, Brian F., Pearson, Ewan R., Boreham, Colin A.G., Cooper, Cyrus, Gillman, Matthew W., Dedoussis, George V., Moreno, Luis A, Pedersen, Oluf, Saarinen, Maiju, Mohlke, Karen L., Boomsma, Dorret I., Saw, Seang-Mei, Lakka, Timo A., Körner, Antje, Loos, Ruth J.F., Ong, Ken K., Vollenweider, Peter, van Duijn, Cornelia M., Koppelman, Gerard H., Hattersley, Andrew T., Holloway, John W., Hocher, Berthold, Heinrich, Joachim, Power, Chris, Melbye, Mads, Guxens, Mònica, Pennell, Craig E., Bønnelykke, Klaus, Bisgaard, Hans, Eriksson, Johan G., Widén, Elisabeth, Hakonarson, Hakon, Uitterlinden, André G., Pouta, Anneli, Lawlor, Debbie A., Smith, George Davey, Frayling, Timothy M., McCarthy, Mark I., Grant, Struan F.A., Jaddoe, Vincent W.V., Jarvelin, Marjo-Riitta, Timpson, Nicholas J., Prokopenko, Inga, Freathy, Rachel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605762/
https://www.ncbi.nlm.nih.gov/pubmed/23202124
http://dx.doi.org/10.1038/ng.2477