Non-canonical Guanine recognition mediates KSRP regulation of Let-7 biogenesis

Let-7 is an important tumor-suppressive microRNA that acts as an on-off switch for cellular differentiation and regulates the expression of a set of human oncogenes. Binding of the human KSRP protein to Let-7 miRNA precursors positively regulates their processing to mature Let-7, thereby contributin...

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Detalles Bibliográficos
Autores principales: Nicastro, Giuseppe, García-Mayoral, María Flor, Hollingworth, David, Kelly, Geoff, Martin, Stephen R., Briata, Paola, Gherzi, Roberto, Ramos, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605776/
https://www.ncbi.nlm.nih.gov/pubmed/23142982
http://dx.doi.org/10.1038/nsmb.2427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605776/
https://www.ncbi.nlm.nih.gov/pubmed/23142982
http://dx.doi.org/10.1038/nsmb.2427

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