Central Synapses Release a Resource-Efficient Amount of Glutamate

Why synapses release a certain amount of neurotransmitter is poorly understood. Here we combine patch-clamp electrophysiology with computer simulations to estimate how much glutamate is discharged at two distinct central synapses of the rat. We find that, regardless of some uncertainty over synaptic...

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Autores principales: Savtchenko, Leonid P., Sylantyev, Sergiy, Rusakov, Dmitri A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605778/
https://www.ncbi.nlm.nih.gov/pubmed/23242311
http://dx.doi.org/10.1038/nn.3285
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author Savtchenko, Leonid P.
Sylantyev, Sergiy
Rusakov, Dmitri A.
author_facet Savtchenko, Leonid P.
Sylantyev, Sergiy
Rusakov, Dmitri A.
author_sort Savtchenko, Leonid P.
collection PubMed
description Why synapses release a certain amount of neurotransmitter is poorly understood. Here we combine patch-clamp electrophysiology with computer simulations to estimate how much glutamate is discharged at two distinct central synapses of the rat. We find that, regardless of some uncertainty over synaptic microenvironment, synapses generate the maximal current per released glutamate molecule while maximizing signal information content. Our result suggests that synapses operate on a principle of resource optimization.
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spelling pubmed-36057782013-07-01 Central Synapses Release a Resource-Efficient Amount of Glutamate Savtchenko, Leonid P. Sylantyev, Sergiy Rusakov, Dmitri A. Nat Neurosci Article Why synapses release a certain amount of neurotransmitter is poorly understood. Here we combine patch-clamp electrophysiology with computer simulations to estimate how much glutamate is discharged at two distinct central synapses of the rat. We find that, regardless of some uncertainty over synaptic microenvironment, synapses generate the maximal current per released glutamate molecule while maximizing signal information content. Our result suggests that synapses operate on a principle of resource optimization. 2012-12-16 2013-01 /pmc/articles/PMC3605778/ /pubmed/23242311 http://dx.doi.org/10.1038/nn.3285 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Savtchenko, Leonid P.
Sylantyev, Sergiy
Rusakov, Dmitri A.
Central Synapses Release a Resource-Efficient Amount of Glutamate
title Central Synapses Release a Resource-Efficient Amount of Glutamate
title_full Central Synapses Release a Resource-Efficient Amount of Glutamate
title_fullStr Central Synapses Release a Resource-Efficient Amount of Glutamate
title_full_unstemmed Central Synapses Release a Resource-Efficient Amount of Glutamate
title_short Central Synapses Release a Resource-Efficient Amount of Glutamate
title_sort central synapses release a resource-efficient amount of glutamate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605778/
https://www.ncbi.nlm.nih.gov/pubmed/23242311
http://dx.doi.org/10.1038/nn.3285
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