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The Human CD8β M-4 Isoform Dominant in Effector Memory T Cells Has Distinct Cytoplasmic Motifs That Confer Unique Properties

The CD8 co-receptor influences T cell recognition and responses in both anti-tumor and anti-viral immunity. During evolution in the ancestor of humans and chimpanzees, the CD8B gene acquired two additional exons. As a result, in humans, there are four CD8β splice variants (M1 to M4) that differ in t...

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Detalles Bibliográficos
Autores principales: Thakral, Deepshi, Coman, Maria M., Bandyopadhyay, Arunima, Martin, Sunil, Riley, James L., Kavathas, Paula B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606432/
https://www.ncbi.nlm.nih.gov/pubmed/23533620
http://dx.doi.org/10.1371/journal.pone.0059374