A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

Besides logistical and ethical concerns, evaluation of safety and efficacy of medications in pregnant women is complicated by marked changes in pharmacokinetics (PK) of drugs. For example, CYP3A activity is induced during the third trimester (T(3)). We explored whether a previously published physiol...

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Detalles Bibliográficos
Autores principales: Ke, A B, Nallani, S C, Zhao, P, Rostami-Hodjegan, A, Unadkat, J D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606941/
https://www.ncbi.nlm.nih.gov/pubmed/23835883
http://dx.doi.org/10.1038/psp.2012.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606941/
https://www.ncbi.nlm.nih.gov/pubmed/23835883
http://dx.doi.org/10.1038/psp.2012.2

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