Androgen deprivation promotes intratumoral synthesis of dihydrotestosterone from androgen metabolites in prostate cancer

Intratumoral synthesis of dihydrotestosterone (DHT) from precursors cannot completely explain the castration resistance of prostate cancer. We showed that DHT was intratumorally synthesized from the inactive androgen metabolites 5α-androstane-3α/β,17β-diol (3α/β-diol) in prostate cancer cells via di...

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Detalles Bibliográficos
Autores principales: Ishizaki, Fumio, Nishiyama, Tsutomu, Kawasaki, Takashi, Miyashiro, Yoshimichi, Hara, Noboru, Takizawa, Itsuhiro, Naito, Makoto, Takahashi, Kota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607121/
https://www.ncbi.nlm.nih.gov/pubmed/23524847
http://dx.doi.org/10.1038/srep01528

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607121/
https://www.ncbi.nlm.nih.gov/pubmed/23524847
http://dx.doi.org/10.1038/srep01528

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