Two Mechanisms Produce Mutation Hotspots at DNA Breaks in Escherichia coli

Mutation hotspots and showers occur across phylogeny and profoundly influence genome evolution, yet the mechanisms that produce hotspots remain obscure. We report that DNA double-strand breaks (DSBs) provoke mutation hotspots via stress-induced mutation in Escherichia coli. With tet reporters placed...

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Detalles Bibliográficos
Autores principales: Shee, Chandan, Gibson, Janet L., Rosenberg, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607216/
https://www.ncbi.nlm.nih.gov/pubmed/23041320
http://dx.doi.org/10.1016/j.celrep.2012.08.033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607216/
https://www.ncbi.nlm.nih.gov/pubmed/23041320
http://dx.doi.org/10.1016/j.celrep.2012.08.033

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