RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL fusion proteins have distinct leuke...

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Detalles Bibliográficos
Autores principales: Wilkinson, Adam C., Ballabio, Erica, Geng, Huimin, North, Phillip, Tapia, Marta, Kerry, Jon, Biswas, Debabrata, Roeder, Robert G., Allis, C. David, Melnick, Ari, de Bruijn, Marella F.T.R., Milne, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607232/
https://www.ncbi.nlm.nih.gov/pubmed/23352661
http://dx.doi.org/10.1016/j.celrep.2012.12.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607232/
https://www.ncbi.nlm.nih.gov/pubmed/23352661
http://dx.doi.org/10.1016/j.celrep.2012.12.016

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