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RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

Vesicular structures called microvesicles (MV) that are shed from the surfaces of cancer cells are capable of transferring oncogenic cargo to recipient cancer cells, as well as to normal cells, sending mitogenic signals that greatly enhance tumor growth. Because MVs are stable in the circulation, th...

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Detalles Bibliográficos
Autores principales: Li, Bo, Antonyak, Marc A., Zhang, Jingwen, Cerione, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607381/
https://www.ncbi.nlm.nih.gov/pubmed/22266864
http://dx.doi.org/10.1038/onc.2011.636