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Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk

Although marrow adipocytes and osteoblasts derive from a common bone marrow stromal cells (BMSCs), the mechanisms that underlie osteoporosis-associated bone loss and marrow adipogenesis during prolonged steroid treatment are unclear. We show in human BMSCs (hBMSCs) that glucocorticoid receptor (GR)...

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Detalles Bibliográficos
Autores principales: Cárcamo-Orive, Iván, Gaztelumendi, Ainhoa, Delgado, Jesús, Tejados, Naiara, Dorronsoro, Akaitz, Fernández-Rueda, Jon, Pennington, Daniel J, Trigueros, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607410/
https://www.ncbi.nlm.nih.gov/pubmed/20499359
http://dx.doi.org/10.1002/jbmr.120