Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase

The anti-AIDS drug rilpivirine undergoes conformational changes to bind HIV-1 reverse transcriptase and retain potency against drug-resistance mutations. Our discovery that water molecules play an essential role in the drug binding is reported. Femtosecond experiments and theory expose molecular lev...

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Detalles Bibliográficos
Autores principales: Kuroda, Daniel G., Bauman, Joseph D., Challa, J. Reddy, Patel, Disha, Troxler, Thomas, Das, Kalyan, Arnold, Eddy, Hochstrasser, Robin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607437/
https://www.ncbi.nlm.nih.gov/pubmed/23422558
http://dx.doi.org/10.1038/nchem.1559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607437/
https://www.ncbi.nlm.nih.gov/pubmed/23422558
http://dx.doi.org/10.1038/nchem.1559

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