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Protein Kinase G1 α Overexpression Increases Stem Cell Survival and Cardiac Function after Myocardial Infarction

BACKGROUND: We hypothesized that overexpression of cGMP-dependent protein kinase type 1α (PKG1α) could mimic the effect of tadalafil on the survival of bone marrow derived mesenchymal stem cells (MSCs) contributing to regeneration of the ischemic heart. METHODS AND RESULTS: MSCs from male rats were...

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Detalles Bibliográficos
Autores principales: Wang, Linlin, Pasha, Zeeshan, Wang, Shuyun, Li, Ning, Feng, Yuliang, Lu, Gang, Millard, Ronald W., Ashraf, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607603/
https://www.ncbi.nlm.nih.gov/pubmed/23536905
http://dx.doi.org/10.1371/journal.pone.0060087