Cargando…

Telomerase Reverse Transcriptase (TERT) is a Therapeutic Target of Oleanane Triterpenoid CDDO-Me in Prostate Cancer

Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) is an synthetic oleanane triterpenoid with strong antiprolifertive and proapoptotic activities in cancer cells. However, the effect of CDDO-Me on human telomerase reverse transcriptase (hTERT) and its telomerase activity in prostate canc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yongbo, Gao, Xiaohua, Deeb, Dorrah, Arbab, Ali S., Gautam, Subhash C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607816/ https://www.ncbi.nlm.nih.gov/pubmed/23519253 http://dx.doi.org/10.3390/molecules171214795

Ejemplares similares

Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent
por: Deeb, Dorrah, et al.
Publicado: (2013)

Prevention of Prostate Cancer with Oleanane Synthetic Triterpenoid CDDO-Me in the TRAMP Mouse Model of Prostate Cancer
por: Gao, Xiaohua, et al.
Publicado: (2011)

CDDO-Me: A Novel Synthetic Triterpenoid for the Treatment of Pancreatic Cancer
por: Deeb, Dorrah, et al.
Publicado: (2010)

Induction of Apoptosis in Pancreatic Cancer Cells by CDDO-Me Involves Repression of Telomerase through Epigenetic Pathways
por: Deeb, Dorrah, et al.
Publicado: (2014)

CDDO-Me inhibits tumor growth and prevents recurrence of pancreatic ductal adenocarcinoma
por: GAO, XIAOHUA, et al.
Publicado: (2015)

Inhibition of hTERT/telomerase contributes to the antitumor activity of pristimerin in pancreatic ductal adenocarcinoma cells
por: DEEB, DORRAH, et al.
Publicado: (2015)

Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway
por: Ryu, Keinosuke, et al.
Publicado: (2010)

Synthesis and Anticancer Activity of CDDO and CDDO-Me, Two Derivatives of Natural Triterpenoids
por: Borella, Rebecca, et al.
Publicado: (2019)

The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity
por: Casares, Laura, et al.
Publicado: (2022)

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC
por: Khattar, Ekta, et al.
Publicado: (2017)

The Triterpenoid CDDO-Me Inhibits Bleomycin-Induced Lung Inflammation and Fibrosis
por: Kulkarni, Ajit A., et al.
Publicado: (2013)

Telomerase Reverse Transcriptase (TERT) in Action: Cross-Talking with Epigenetics
por: Yuan, Xiaotian, et al.
Publicado: (2019)

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer
por: Yang, Ruozhu, et al.
Publicado: (2023)

Differential expression of telomerase reverse transcriptase (hTERT) in lung tumours
por: Lantuejoul, S, et al.
Publicado: (2004)

Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
por: Ramlee, Muhammad Khairul, et al.
Publicado: (2016)

Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review
por: McKelvey, Brittany A., et al.
Publicado: (2020)

Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment
por: Wang, Yan-Yang, et al.
Publicado: (2014)

The role of telomerase reverse transcriptase (TERT) promoter mutations in prognosis in bladder cancer
por: Wan, Song, et al.
Publicado: (2021)

Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutations
por: Tornesello, Maria Lina, et al.
Publicado: (2023)

Human Telomerase Reverse Transcriptase (hTERT) Q169 Is Essential for Telomerase Function In Vitro and In Vivo
por: Wyatt, Haley D. M., et al.
Publicado: (2009)

Pristimerin, a quinonemethide triterpenoid, induces apoptosis in pancreatic cancer cells through the inhibition of pro-survival Akt/NF-κB/mTOR signaling proteins and anti-apoptotic Bcl-2
por: DEEB, DORRAH, et al.
Publicado: (2014)

Chemical and Biological Characterization of Oleanane Triterpenoids from Soy
por: Zhang, Wei, et al.
Publicado: (2009)

Cancer-Specific Telomerase Reverse Transcriptase (TERT) Promoter Mutations: Biological and Clinical Implications
por: Liu, Tiantian, et al.
Publicado: (2016)

Mechanisms of human telomerase reverse transcriptase (hTERT) regulation: clinical impacts in cancer
por: Leão, Ricardo, et al.
Publicado: (2018)

Exploring the epigenetic regulation of telomerase reverse transcriptase (TERT) in human cancer cell lines
por: McKelvey, Brittany A., et al.
Publicado: (2020)

Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia
por: Yik, Mot Yee, et al.
Publicado: (2021)

An Identification and Characterization of the Axolotl (Ambystoma mexicanum, Amex) Telomerase Reverse Transcriptase (Amex TERT)
por: Springhetti, Sina, et al.
Publicado: (2022)

Allele‐specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers
por: Rowland, Teisha J., et al.
Publicado: (2020)

The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients
por: Rampazzo, Enrica, et al.
Publicado: (2018)

SAT630 Analytical Validation Of A Telomerase Reverse Transcriptase (TERT) Promoter Mutation Assay
por: Iyer, Priyanka, et al.
Publicado: (2023)

Biological Evaluation and Docking Studies of Synthetic Oleanane-type Triterpenoids
por: Ortega-Muñoz, Mariano, et al.
Publicado: (2018)

The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage
por: Amirova, Kristiana M., et al.
Publicado: (2023)

Telomerase reverse transcriptase and neurodegenerative diseases
por: Yu, Xin, et al.
Publicado: (2023)

Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms
por: Xu, D, et al.
Publicado: (1999)

Naïve T-cells in Myelodysplastic Syndrome Display Intrinsic Human Telomerase Reverse Transcriptase (hTERT) Deficiency
por: Yang, Lili, et al.
Publicado: (2012)

Correction: The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients
por: Rampazzo, Enrica, et al.
Publicado: (2018)

DNA Hypermethylation Downregulates Telomerase Reverse Transcriptase (TERT) during H. pylori-Induced Chronic Inflammation
por: Bussière, Françoise I., et al.
Publicado: (2019)

Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes
por: Plyasova, Anna A., et al.
Publicado: (2021)

Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter
por: Gu, Wei, et al.
Publicado: (2022)

Copy-number-gain of telomerase reverse transcriptase (hTERT) is associated with an unfavorable prognosis in esophageal adenocarcinoma
por: Lyu, Su Ir, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_sr28m20g8bsph3l3otfd36ttr9