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Ca(2+) block and flickering both contribute to the negative slope of the IV curve in BK channels
Single-channel current–voltage (IV) curves of human large-conductance, voltage- and Ca(2+)-activated K(+) (BK) channels are quite linear in 150 mM KCl. In the presence of Ca(2+) and/or Mg(2+), they show a negative slope conductance at high positive potentials. This is generally explained by a Ca(2+)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607826/ https://www.ncbi.nlm.nih.gov/pubmed/23530139 http://dx.doi.org/10.1085/jgp.201210956 |