Beclin1 inhibition promotes autophagy and decreases gemcitabine–induced apoptosis in Miapaca2 pancreatic cancer cells

BACKGROUND: Beclin1 is a well-known key regulator of autophagy, which is also a haploinsufficient tumor suppressor. Current studies revealed that down-regulation or monoallelic deletions of Beclin1 were frequently found in various cancers. The purpose of this study was to investigate the effects of...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xiaoshu, Yan, Jun, Wang, Lisheng, Xiao, Fengjun, Yang, Yuefeng, Guo, Xiaozhong, Wang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607839/
https://www.ncbi.nlm.nih.gov/pubmed/23497401
http://dx.doi.org/10.1186/1475-2867-13-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607839/
https://www.ncbi.nlm.nih.gov/pubmed/23497401
http://dx.doi.org/10.1186/1475-2867-13-26

Ejemplares similares