Cargando…

Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG

BACKGROUND: New tuberculosis (TB) vaccines are being developed to combat the global epidemic. A phase IIb trial of a candidate vaccine, MVA85A, was conducted in a high burden setting in South Africa to evaluate proof-of-concept efficacy for prevention of TB in infants. OBJECTIVE: To describe the stu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tameris, Michele, McShane, Helen, McClain, J. Bruce, Landry, Bernard, Lockhart, Stephen, Luabeya, Angelique K.K., Geldenhuys, Hennie, Shea, Jacqui, Hussey, Gregory, van der Merwe, Linda, de Kock, Marwou, Scriba, Thomas, Walker, Robert, Hanekom, Willem, Hatherill, Mark, Mahomed, Hassan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Churchill Livingstone 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608032/ https://www.ncbi.nlm.nih.gov/pubmed/23410889 http://dx.doi.org/10.1016/j.tube.2013.01.003

Ejemplares similares

The Role of Clinical Symptoms in the Diagnosis of Intrathoracic Tuberculosis in Young Children
por: Mulenga, Humphrey, et al.
Publicado: (2015)

Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial
por: Tameris, Michele D, et al.
Publicado: (2013)

Comparison of haematology and biochemistry parameters in healthy South African infants with laboratory reference intervals
por: Schmidt, B.‐M., et al.
Publicado: (2017)

The Candidate TB Vaccine, MVA85A, Induces Highly Durable Th1 Responses
por: Tameris, Michele, et al.
Publicado: (2014)

Risk of Disease After Isoniazid Preventive Therapy for Mycobacterium tuberculosis Exposure in Young HIV-uninfected Children
por: Luabeya, Kany Kany A., et al.
Publicado: (2015)

Evaluation of Xpert(®) MTB/RIF Assay in Induced Sputum and Gastric Lavage Samples from Young Children with Suspected Tuberculosis from the MVA85A TB Vaccine Trial
por: Bunyasi, Erick Wekesa, et al.
Publicado: (2015)

Impact of isoniazid preventive therapy on the evaluation of long-term effectiveness of infant MVA85A vaccination
por: Bunyasi, E. W., et al.
Publicado: (2017)

A randomized clinical trial in adults and newborns in South Africa to compare the safety and immunogenicity of bacille Calmette-Guérin (BCG) vaccine administration via a disposable-syringe jet injector to conventional technique with needle and syringe
por: Geldenhuys, Hennie D., et al.
Publicado: (2015)

T-cell activation is an immune correlate of risk in BCG vaccinated infants
por: Fletcher, Helen A., et al.
Publicado: (2016)

Corrigendum: T-cell activation is an immune correlate of risk in BCG vaccinated infants
por: Fletcher, Helen A., et al.
Publicado: (2016)

Prevalence of latent TB infection and TB disease among adolescents in high TB burden countries in Africa: a systematic review protocol
por: Bunyasi, Erick Wekesa, et al.
Publicado: (2017)

TB Incidence in an Adolescent Cohort in South Africa
por: Mahomed, Hassan, et al.
Publicado: (2013)

Comparison of Mantoux and Tine Tuberculin Skin Tests in BCG-Vaccinated Children Investigated for Tuberculosis
por: Pan, Wenli, et al.
Publicado: (2009)

Isolation of Non-Tuberculous Mycobacteria in Children Investigated for Pulmonary Tuberculosis
por: Hatherill, Mark, et al.
Publicado: (2006)

Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial
por: Hawkridge, Anthony, et al.
Publicado: (2008)

Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced IL-6 secretion
por: Shehu Shey, Muki, et al.
Publicado: (2010)

Inflammation and immune activation are associated with risk of Mycobacterium tuberculosis infection in BCG-vaccinated infants
por: Satti, Iman, et al.
Publicado: (2022)

Inflammatory and myeloid-associated gene expression before and one day after infant vaccination with MVA85A correlates with induction of a T cell response
por: Matsumiya, Magali, et al.
Publicado: (2014)

Cytomegalovirus infection is a risk factor for tuberculosis disease in infants
por: Müller, Julius, et al.
Publicado: (2019)

Elevated IgG Responses in Infants Are Associated With Reduced Prevalence of Mycobacterium tuberculosis Infection
por: Logan, Erin, et al.
Publicado: (2018)

Heterologous vaccination against human tuberculosis modulates antigen-specific CD4(+) T-cell function
por: Dintwe, One B, et al.
Publicado: (2013)

Association of Human TLR1 and TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants
por: Randhawa, April Kaur, et al.
Publicado: (2011)

Serum indoleamine 2,3-dioxygenase activity is associated with reduced immunogenicity following vaccination with MVA85A
por: Tanner, Rachel, et al.
Publicado: (2014)

Prevention of Infection with Mycobacterium tuberculosis by H4:IC31® Vaccination or BCG Revaccination in Adolescents
por: Nemes, Elisa, et al.
Publicado: (2018)

Effects of MVA85A vaccine on tuberculosis challenge in animals: systematic review
por: McShane, Helen, et al.
Publicado: (2016)

Regional changes in tuberculosis disease burden among adolescents in South Africa (2005–2015)
por: Bunyasi, Erick Wekesa, et al.
Publicado: (2020)

Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin for Infants of Human Immunodeficiency Virus-Infected Mothers: A Phase 2 Randomized, Controlled Trial
por: Nemes, Elisa, et al.
Publicado: (2018)

Process of Assay Selection and Optimization for the Study of Case and Control Samples from a Phase IIb Efficacy Trial of a Candidate Tuberculosis Vaccine, MVA85A
por: Harris, Stephanie A., et al.
Publicado: (2014)

Editorial Commentary: Understanding BCG Is the Key to Improving It
por: McShane, Helen
Publicado: (2014)

Application of a whole blood mycobacterial growth inhibition assay to study immunity against Mycobacterium tuberculosis in a high tuberculosis burden population
por: Baguma, Richard, et al.
Publicado: (2017)

Correction: The Tuberculin Skin Test versus QuantiFERON TB Gold® in Predicting Tuberculosis Disease in an Adolescent Cohort Study in South Africa
por: Mahomed, Hassan, et al.
Publicado: (2011)

The Tuberculin Skin Test versus QuantiFERON TB Gold® in Predicting Tuberculosis Disease in an Adolescent Cohort Study in South Africa
por: Mahomed, Hassan, et al.
Publicado: (2011)

Safety and immunogenicity of candidate vaccine M72/AS01(E) in adolescents in a TB endemic setting
por: Penn-Nicholson, Adam, et al.
Publicado: (2015)

Differential DNA methylation of potassium channel KCa3.1 and immune signalling pathways is associated with infant immune responses following BCG vaccination
por: Hasso-Agopsowicz, Mateusz, et al.
Publicado: (2018)

The Humoral Immune Response to BCG Vaccination
por: Tanner, Rachel, et al.
Publicado: (2019)

What Have We Learnt about BCG Vaccination in the Last 20 Years?
por: Dockrell, Hazel M., et al.
Publicado: (2017)

Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth
por: Fletcher, Helen A, et al.
Publicado: (2009)

Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?
por: Saiz, Juan-Carlos, et al.
Publicado: (2017)

BCG vaccination in England since 2005: a survey of policy and practice
por: Pilger, Daniel, et al.
Publicado: (2012)

Effects of BCG vaccination on donor unrestricted T cells in two prospective cohort studies
por: Gela, Anele, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gf1cotu1fdvhclmieuc68hdbfi