Means of self-preservation: how an intrinsically disordered ubiquitin-protein ligase averts self-destruction

Ubiquitin-protein ligases (E3s) that ubiquitinate substrates for proteasomal degradation are often in the position of ubiquitinating themselves due to interactions with a charged ubiquitin-conjugating enzyme (E2). This can mediate the E3’s proteasomal degradation. Many E3s have evolved means to avoi...

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Detalles Bibliográficos
Autores principales: Fredrickson, Eric K., Clowes Candadai, Sarah V., Tam, Cheuk Ho, Gardner, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608492/
https://www.ncbi.nlm.nih.gov/pubmed/23363599
http://dx.doi.org/10.1091/mbc.E12-11-0811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608492/
https://www.ncbi.nlm.nih.gov/pubmed/23363599
http://dx.doi.org/10.1091/mbc.E12-11-0811

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