Central role of the exchange factor GEF-H1 in TNF-α–induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells

Transactivation of the epidermal growth factor receptor (EGFR) by tumor necrosis factor-α (TNF-α) is a key step in mediating RhoA activation and cytoskeleton and junction remodeling in the tubular epithelium. In this study we explore the mechanisms underlying TNF-α–induced EGFR activation. We show t...

Descripción completa

Detalles Bibliográficos
Autores principales: Waheed, Faiza, Dan, Qinghong, Amoozadeh, Yasaman, Zhang, Yuqian, Tanimura, Susumu, Speight, Pam, Kapus, András, Szászi, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608494/
https://www.ncbi.nlm.nih.gov/pubmed/23389627
http://dx.doi.org/10.1091/mbc.E12-09-0661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608494/
https://www.ncbi.nlm.nih.gov/pubmed/23389627
http://dx.doi.org/10.1091/mbc.E12-09-0661

Ejemplares similares