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Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils
PMEL (also called Pmel17 or gp100) is a melanocyte/melanoma-specific glycoprotein that plays a critical role in melanosome development by forming a fibrillar amyloid matrix in the organelle for melanin deposition. Although ultimately not a component of mature fibrils, the PMEL N-terminal region (NTR...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608505/ https://www.ncbi.nlm.nih.gov/pubmed/23389629 http://dx.doi.org/10.1091/mbc.E12-10-0742 |