Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines

Three-dimensional (3D) tumor cell cultures grown in laminin-rich-extracellular matrix (lrECM) are considered to reflect human tumors more realistic as compared to cells grown as monolayer on plastic. Here, we systematically investigated the impact of ECM on phenotype, gene expression, EGFR signaling...

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Detalles Bibliográficos
Autores principales: Luca, Anna C., Mersch, Sabrina, Deenen, René, Schmidt, Stephan, Messner, Isabelle, Schäfer, Karl-Ludwig, Baldus, Stephan E., Huckenbeck, Wolfgang, Piekorz, Roland P., Knoefel, Wolfram T., Krieg, Andreas, Stoecklein, Nikolas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608563/
https://www.ncbi.nlm.nih.gov/pubmed/23555746
http://dx.doi.org/10.1371/journal.pone.0059689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608563/
https://www.ncbi.nlm.nih.gov/pubmed/23555746
http://dx.doi.org/10.1371/journal.pone.0059689

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