Cargando…

The p14ARF Alternate Reading Frame Protein Enhances DNA Binding of Topoisomerase I by Interacting with the Serine 506-Phosphorylated Core Domain

In addition to its well-characterized function as a tumor suppressor, p14ARF (ARF) is a positive regulator of topoisomerase I (topo I), a central enzyme in DNA metabolism and a target for cancer therapy. We previously showed that topo I hyperphosphorylation, a cancer-associated event mediated by ele...

Descripción completa

Detalles Bibliográficos
Autores principales: Bandyopadhyay, Keya, Li, Pingchuan, Gjerset, Ruth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608632/
https://www.ncbi.nlm.nih.gov/pubmed/23555599
http://dx.doi.org/10.1371/journal.pone.0058835