Global Conformational Selection and Local Induced Fit for the Recognition between Intrinsic Disordered p53 and CBP

The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription. NMR experiments demonstrate that both apo-NCBD and TAD are intrinsic disordered and bound NCBD/TAD und...

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Detalles Bibliográficos
Autores principales: Yu, Qingfen, Ye, Wei, Wang, Wei, Chen, Hai-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608666/
https://www.ncbi.nlm.nih.gov/pubmed/23555731
http://dx.doi.org/10.1371/journal.pone.0059627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608666/
https://www.ncbi.nlm.nih.gov/pubmed/23555731
http://dx.doi.org/10.1371/journal.pone.0059627

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