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Global Conformational Selection and Local Induced Fit for the Recognition between Intrinsic Disordered p53 and CBP
The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription. NMR experiments demonstrate that both apo-NCBD and TAD are intrinsic disordered and bound NCBD/TAD und...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608666/ https://www.ncbi.nlm.nih.gov/pubmed/23555731 http://dx.doi.org/10.1371/journal.pone.0059627 |