Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity

Our research proved that chemical character of the C-5 substituent significantly determines the antibacterial activity of the Mannich bases derived from 4,5-disubstituted 1,2,4-triazole-3-thiones. This activity was considerably increased by an introduction of a chlorine atom to the phenyl ring. The...

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Autores principales: Plech, Tomasz, Wujec, Monika, Majewska, Magdalena, Kosikowska, Urszula, Malm, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608860/
https://www.ncbi.nlm.nih.gov/pubmed/23543889
http://dx.doi.org/10.1007/s00044-012-0248-y
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author Plech, Tomasz
Wujec, Monika
Majewska, Magdalena
Kosikowska, Urszula
Malm, Anna
author_facet Plech, Tomasz
Wujec, Monika
Majewska, Magdalena
Kosikowska, Urszula
Malm, Anna
author_sort Plech, Tomasz
collection PubMed
description Our research proved that chemical character of the C-5 substituent significantly determines the antibacterial activity of the Mannich bases derived from 4,5-disubstituted 1,2,4-triazole-3-thiones. This activity was considerably increased by an introduction of a chlorine atom to the phenyl ring. The obtained compounds were particularly active against opportunistic bacteria (Bacillus subtilis and Bacillus cereus). The antibacterial activity of some Mannich bases was similar or higher than the activity of commonly used antibiotics such as ampicillin and cefuroxime.
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spelling pubmed-36088602013-03-28 Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity Plech, Tomasz Wujec, Monika Majewska, Magdalena Kosikowska, Urszula Malm, Anna Med Chem Res Original Research Our research proved that chemical character of the C-5 substituent significantly determines the antibacterial activity of the Mannich bases derived from 4,5-disubstituted 1,2,4-triazole-3-thiones. This activity was considerably increased by an introduction of a chlorine atom to the phenyl ring. The obtained compounds were particularly active against opportunistic bacteria (Bacillus subtilis and Bacillus cereus). The antibacterial activity of some Mannich bases was similar or higher than the activity of commonly used antibiotics such as ampicillin and cefuroxime. Springer-Verlag 2012-09-29 2013 /pmc/articles/PMC3608860/ /pubmed/23543889 http://dx.doi.org/10.1007/s00044-012-0248-y Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Research
Plech, Tomasz
Wujec, Monika
Majewska, Magdalena
Kosikowska, Urszula
Malm, Anna
Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity
title Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity
title_full Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity
title_fullStr Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity
title_full_unstemmed Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity
title_short Microbiologically active Mannich bases derived from 1,2,4-triazoles. The effect of C-5 substituent on antibacterial activity
title_sort microbiologically active mannich bases derived from 1,2,4-triazoles. the effect of c-5 substituent on antibacterial activity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608860/
https://www.ncbi.nlm.nih.gov/pubmed/23543889
http://dx.doi.org/10.1007/s00044-012-0248-y
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