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BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state

BACKGROUND: Chronic pain is an important medical problem affecting hundreds of millions of people worldwide. Mechanisms underlying the maintenance of chronic pain states are poorly understood but the elucidation of such mechanisms have the potential to reveal novel therapeutics capable of reversing...

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Detalles Bibliográficos
Autores principales: Melemedjian, Ohannes K, Tillu, Dipti V, Asiedu, Marina N, Mandell, Edward K, Moy, Jamie K, Blute, Victoria M, Taylor, Caleb J, Ghosh, Sourav, Price, Theodore J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608966/
https://www.ncbi.nlm.nih.gov/pubmed/23510079
http://dx.doi.org/10.1186/1744-8069-9-12