Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding

The recently discovered 150-cavity (formed by loop residues 147–152, N2 numbering) adjacent to the enzymatic active site of group 1 influenza A neuraminidase (NA) has introduced a novel target for the design of next-generation NA inhibitors. However, only group 1 NAs, with the exception of the 2009...

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Detalles Bibliográficos
Autores principales: Wu, Yan, Qin, Guangrong, Gao, Feng, Liu, Yue, Vavricka, Christopher J., Qi, Jianxun, Jiang, Hualiang, Yu, Kunqian, Gao, George F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609017/
https://www.ncbi.nlm.nih.gov/pubmed/23531861
http://dx.doi.org/10.1038/srep01551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609017/
https://www.ncbi.nlm.nih.gov/pubmed/23531861
http://dx.doi.org/10.1038/srep01551

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